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neuCompLab

Mederos & Valero lab

PUBLICATIONS

Cooperative actions of interneuron families support the hippocampal spatial code
Science 389, 6764

2025

Valero M†*, Abad-Perez P†, Gallardo A, Picco M, García-Hernandez R, Brotons J, Martínez-Félix A, Machold R, Rudy B, Buzsáki G*
Fear protects. Until it doesn't.: The brain learns to suppress instinctive defensive responses when threats prove harmless
Science 390(6772), 483

2025

Mederos S (Eppendof and Science prize for neurobiology Essay)
Overwriting an instinct: Visual cortex instructs learning to suppress fear responses
Science 387(6734), 682-688

2025

Mederos S*, Blakely P, Vissers N, Clopath C, Hofer S*
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Science 375 (6580), 570-574

2022

Valero M*, Zutshi I, Yoon E, Buzsáki G*
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex
Nature Neuroscience 24, 401-411

2021

Valero M, Viney T, Machold R, Mederos S, Zutshi I, Schuman B, Senzai Y, Rudy B & Buzsáki G
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Nature Neuroscience 24(1), 82-92

2020

Mederos S, Sánchez-Puelles C, Esparza J, Valero M, Ponomarenko A, Perea G
Mechanisms for selective single-cell reactivation during offline sharp-wave ripples and their distortion by fast ripples
Neuron 94(6), 1234–1247

2017

Valero M, Averkin RG, Fernandez-Lamo I, Aguilar J, Lopez-Pigozzi D, Brotons-Mas JR, Cid E, Tamas G, Menendez de la Prida L
Determinants of different deep/superficial CA1 pyramidal cell dynamics during sharp-wave-ripples
Nature Neuroscience 18, 1281–1290

2015

Valero M, Cid E, Averkin RG, Aguilar J, Sanchez-Aguilera A, Viney T, Gomez-Dominguez D, Bellistri E and Menendez de la Prida L

PEOPLE

Manuel Valero
Group Leader
Ramon y Cajal Group Leader at Hospital del Mar Medical Research Institute (HMRIB).
Sara Mederos
Group Leader
Ramon y Cajal Group Leader at Hospital del Mar Medical Research Institute (HMRIB)
Andrea Gallardo
Undergraduate Student
Ephys, spike sorting and data analysis.
Pablo Abad
Postdoctoral Researcher
Ephys and data analysis.
Antonio Florido
Postdoctoral Researcher
Miniscope, ephys and stress models
Marta Picco
FPI PhD Student
Modeling and data analysis.
Anel Martínez-Félix
Joan Oró PhD Student
Simultaneous fiber photometry-ephys and behaviour.
Ignacio del Castillo
La Caixa INPhINIT PhD Student
Simultaneous fiber photometry-ephys and behaviour. Astrocytes and memory.
You
We are looking for talented, creative, and motivated students and postdoctoral candidates to join our team.

CONTACT

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Neural Computation Lab (Office 145)
Hospital del Mar Medical Research Institute (IMIM)
Dr. Aiguader, 88, 08003
Barcelona, Spain

I am Manuel Valero, Group Leader at the Hospital del Mar Medical Research Institute (IMIM), Barcelona (Spain). You can find me in Github or send me an email to valegarman@gmail.com